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Chapter: Medicine Study Notes : Pharmacology

Excretion of Drugs - Pharmacokinetics

Excretion: o Major routes renal, hepatobilary, pulmonary o Minor routes: saliva, breast milk, tears

Excretion of Drugs

 

·        Excretion:

o   Major routes renal, hepatobilary, pulmonary

o   Minor routes: saliva, breast milk, tears


·        Renal:

o  Few are excreted unchanged.  Lipid soluble undergo tubular reabsorption 

o  Only unbound particles excreted Þ if highly bound then slower excretion

o  Some are secreted by active tubular secretion e.g. penicillin, digoxin 

o  Urine pH: alkaline urine ® ­weak acid excretion (eg salicylates) and visa versa


·        Bilary:

o  Polar drugs likely to be excreted in bile, e.g. rifampicin, ampicillin

o  Some drugs undergo entero-hepatic circulation, e.g. oestrogens

 

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Medicine Study Notes : Pharmacology : Excretion of Drugs - Pharmacokinetics |


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