Home | | Medicine Study Notes | Steady State Concentration

Chapter: Medicine Study Notes : Pharmacology

Steady State Concentration

Amount of drug absorbed = amount eliminated

Steady State Concentration

 

·        Amount of drug absorbed = amount eliminated

·        Takes 5 half lives to reach 97% of steady state, if each new dose given at half life spacings

·        The shorter the T½, the sooner the Css will be reached (steady state concentration)

·        The shorter the T½, the greater the plasma concentration will fluctuate between doses

·        If T½ is prolonged, dose should be reduced or dosage interval increased

·        Css = (F * D) / (Cl * T) where F = bioavailability, D = dose, Cl = clearance and T = dosage interval

 

§  As Cl = (Vd * 0.693) / T½, then

 

§  Css = (F * D * T½ ) / (0.693 * Vd * T)

 

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Medicine Study Notes : Pharmacology : Steady State Concentration |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.