Home | | Medicine Study Notes | Distribution - Pharmacokinetics

Chapter: Medicine Study Notes : Pharmacology

Distribution - Pharmacokinetics

Drug can be bound or unbound in both plasma and tissues

Distribution

 

·        Drug can be bound or unbound in both plasma and tissues

 

·        Drugs bind to albumin (acidic drugs), a1 acid glycoprotein (basic drugs), tissue proteins


·        Lipid solubility:

o   Penetrate lipid membranes easily (e.g. placenta, blood/brain barrier) 

o   Rapidly distributed, dissolves in fat ® plasma levels fall quickly, and large volume of distribution 

o   Is non-polar or unionised


·        Water soluble:

o   Excreted by kidneys (some also metabolised by liver)

o   Redistributes in water, smaller volume of distribution


·        Ionisation of acid or base:

o   Depends on pH and pKa (the pH at which 50% of drug is ionised) 

o   As pH ­ (becomes more alkaline) an acid becomes more ionised, and a base less ionised

o   Only unionised drug will diffuse across lipid membrane

 

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Medicine Study Notes : Pharmacology : Distribution - Pharmacokinetics |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.