Chapter: Medicine and surgery: Musculoskeletal system

Pseudogout - Crystal arthropathies

A crystal arthropathy resulting from calcium pyrophos-phate dihydrate (CPPD) deposition in the joints. - Definition, Incidence, Aetiology, Pathophysiology, Clinical features

Pseudogout

 

Definition

 

A crystal arthropathy resulting from calcium pyrophos-phate dihydrate (CPPD) deposition in the joints.

 

 

Aetiology/pathophysiology

 

CPPD crystal formation occurs in cartilage located near chondrocytes. It is suggested that excessive cartilage pyrophosphate production leads to local crystal formation. Crystals are thought to enter the joint cavity after being shed from the cartilage in which they have formed.

 

 

Clinical features

 

Chondrocalcinosis may be detected on X-ray in cartilage without joint disease. Acute joint inflammation resembles gout most commonly affecting the knee and other large joints.

 

 

Investigation

 

Examination of the joint fluid will demonstrate positively birefringent crystals.

Management

 

The pain of pseudogout is relieved by nonsteroidal anti-inflammatory drugs, aspiration of synovial fluid and intra-articular steroid injection.

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Medicine and surgery: Musculoskeletal system : Pseudogout - Crystal arthropathies |

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Medicine and surgery: Musculoskeletal system


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