How is susceptibility to MH inherited?
Susceptibility to MH is thought to be inherited by auto-somal dominant pattern with mixed penetrance, although an autosomal recessive form exists as well. Multiple muta-tions for the ryanodine receptor of the sarcoplasmic retic-ulum are causative. Other genes may be involved as well. The identification of a single causative gene, therefore, is not possible. Siblings and children of MH-susceptible individuals experience a 50% risk of susceptibility.