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Describe the neurolept malignant syndrome.
The clinical presentatipn of neurolept malignant syn-drome (NMS) includes fever, tachycardia, hypertension, muscle rigidity, acidosis, rhabdomyolysis, and agitation. Its mortality rate approximates 20% and dantrolene is an effective treatment. It is easily confused with MH.
NMS is distinguished from MH by several features. NMS follows long-term exposure to phenothiazines or haloperidol. Sudden withdrawal of anti-parkinsonism drugs may precipitate NMS.
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