ANTI-MIGRAINE DRUGS
·
Migraine is treated pharmacologically using either an acute,
or prophylactic, or combined medication programme utilising one or more of
several drugs available for the purpose. These drugs include analgesics
(aspirin or paracetamol), anti-emetics (diphenhydramine, prochlorperazine,
promethazine, meto-clopramide), combination analgesics (aspirin or paracetamol
with a mild vasoconstrictor, e.g. isometheptene,* or a sedative, e.g.
butalbital), ergot alkaloids, and sumatriptan. Prophylactic treatment mainly
involves beta -blockers, calcium channel inhibitors, serotonin antagonists, or
antidepressants.
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A detailed discussion on ergot alkaloids and sumatriptan
follows, while all the other drugs have been discussed else-where.
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