· Migraine is treated pharmacologically using either an acute, or prophylactic, or combined medication programme utilising one or more of several drugs available for the purpose. These drugs include analgesics (aspirin or paracetamol), anti-emetics (diphenhydramine, prochlorperazine, promethazine, meto-clopramide), combination analgesics (aspirin or paracetamol with a mild vasoconstrictor, e.g. isometheptene,* or a sedative, e.g. butalbital), ergot alkaloids, and sumatriptan. Prophylactic treatment mainly involves beta -blockers, calcium channel inhibitors, serotonin antagonists, or antidepressants.
· A detailed discussion on ergot alkaloids and sumatriptan follows, while all the other drugs have been discussed else-where.
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