Tiredness
·
Differential:
·
Sleep disturbance: eg anxiety,
sleep apnoea, narcolepsy,
o Depression
o Anaemia
o Endocrine: hypothyroidism, hypocortisol (Addison‟s), diabetes,
hypercalcaemia (due to PTH)
o Infection (eg EBV)
o Cancer
o Drugs: alcohol intoxication, sedative drugs,
o Head injury (eg subdural haematoma)
o Post ictal states
o Hypoglycaemia
o Hepatic encephalopathy, Wernicke‟s encephalopathy
o Chronic heart failure
o Malabsorption (eg coeliac disease)
o Pregnancy
· Sleepiness
·
Varies according to circadian
cycle: two sleep gates each day, 2 – 3 pm and 10 – 11 pm (correlates with melatoin)
·
Obstructive sleep apnoea is the
most common cause of excessive sleepiness. ® MVA (driving drowsy is the same
as driving drunk)
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