Chapter: Biochemistry: Nucleic Acid Metabolism
Processing of mRNA molecules
mRNA undergoes several modifications before it is being translated.
Processing of mRNA molecules
mRNA undergoes several modifications before it
is being translated. They are
1.
Addition
of blocks of poly A, containing 200 (or) more AMP residues to the 3' end of
messenger RNAs. This addition of poly A tail takes place in the nucleus.
2.
A
methylated Guanine nucleotide called as “5' cap” is added to the 5' end of mRNA
molecule.
3.
Methylation
occurs in the internal adenylate nucleotides at their N-6 position. It’s
function is not known.Thus mRNA is processed to get the active mRNA molecule.
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Biochemistry: Nucleic Acid Metabolism