Renal tubular disorders
The renal tubules are responsible
for the regulation of fluid, acid–base, and electrolyte balance. Abnormalities
of renal function may occur at any point along the length of the renal tubule
system and may lead to a distur-bance in the equilibrium of any of the
substances handled by it. It is essen-tial to consider these disorders when
there are any of the following:
·
Glycosuria,
amino-aciduria, or impaired ability to concentrate or acidify urine shown on
urinalysis.
·
Stones or nephrocalcinosis: distal tubular acidosis and
oxalosis are major causes.
·
Polyhydramnios and failure to
thrive in a newborn: e.g.
Bartter syndrome associated with
hypokalaemic alkalosis.
·
Failure to thrive with rickets: cystinosis is commonest cause of
Fanconi syndrome.
·
Major rickets with low plasma
phosphate levels: familial hypophosphataemic rickets.
·
Failure to thrive with low urine
osmolality: nephrogenic
diabetes insipidus.
Renal tubular acidosis (RTA) is a
state of systemic hyperchloraemia result-ing from impaired urinary
acidification. Three types of RTA exist:
· Proximal type.
·
Distal
type.
·
Mineralocorticoid
deficiency-associated.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.