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Chapter: Paediatrics: Growth and puberty

Paediatrics: Chronic inflammatory disorders

Poor growth and short stature is a common feature of long-term inflam-matory conditions such as inflammatory bowel disease and rheumatic dis-orders.

Chronic inflammatory disorders

 

Poor growth and short stature is a common feature of long-term inflam-matory conditions such as inflammatory bowel disease and rheumatic dis-orders. It may be a presenting feature in Crohn’s disease when GI symp-toms are initially minimal.

 

Short stature is due to long-term use of immunosuppressive agents (e.g.

corticosteroids) and to the generation of inflammatory factors (e.g. IL-6).

Both lead to GH/IGF-I resistance and suppression of bone growth.

Management should be aimed at minimizing infl ammation, and reducing immunosuppressive therapy. rhGH may have a role in treatment.

 

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Paediatrics: Growth and puberty : Paediatrics: Chronic inflammatory disorders |


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