Chronic inflammatory disorders
Poor growth and short stature is a
common feature of long-term inflam-matory conditions such as inflammatory bowel
disease and rheumatic dis-orders. It may be a presenting feature in Crohnâ€™s
disease when GI symp-toms are initially minimal.
Short stature is due to long-term
use of immunosuppressive agents (e.g.
corticosteroids) and to the
generation of inflammatory factors (e.g. IL-6).
Both lead to GH/IGF-I resistance
and suppression of bone growth.
Management should be aimed at
minimizing infl ammation, and reducing immunosuppressive therapy. rhGH may have
a role in treatment.