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Chapter: Clinical Anesthesiology: Clinical Pharmacology: Adjuncts to Anesthesia

Neurokinin 1 Receptor Antagonist

Postoperative Nausea & Vomiting PONV

NEUROKININ 1 RECEPTOR ANTAGONIST

Substance P is a neuropeptide that interacts at neu-rokinin-1 (NK₁) receptors. NK ₁ antagonists inhibit substance P at central and peripheral receptors. Aprepitant (Emend), an NK₁ antagonist, has been found to reduce PONV perioperatively and is addi-tive with ondansetron for this indication.

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Clinical Anesthesiology: Clinical Pharmacology: Adjuncts to Anesthesia : Neurokinin 1 Receptor Antagonist |