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NEUROKININ 1 RECEPTOR ANTAGONIST
Substance P is a neuropeptide that interacts at neu-rokinin-1 (NK1) receptors. NK 1 antagonists inhibit substance P at central and peripheral receptors. Aprepitant (Emend), an NK1 antagonist, has been found to reduce PONV perioperatively and is addi-tive with ondansetron for this indication.
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