MEANING OF THE TERMS PEPTIC, GASTRIC AND
DUODENAL ULCER
The term peptic ulcer is used to describe any localized erosion of the
mucosal lining of those portions of the alimentary tract that come in contact
with gastric juice. This disintegration of tissues can also result in necrosis.
Majority of ulcers are found in the duodenum, although they also occur in the
stomach and in the oesophagus. Similar symptoms are produced by the ulcer
regardless of its location and response to treatment is the same.
Duodenal Ulcer
In this condition there is hypersecretion of acid although tissue
resistance is normal. Acid hypersecretion is due to an increased number of
parietal cells and impaired rapid gastric emptying with loss of buffering
effect.
Gastric Ulcer
Patients with gastric ulcer have weakened mucosal resistance caused by
poor nutrition, diminished mucosal blood flow and a defect in the inhibition of
gastric acid and pepsin secretion.
In the
development of gastric ulcers although the presence of acid is essential, the
degree of tissue sensitivity is important. In patients with duodenal ulcer,
excess production of acid and pepsin is the primary factor. Figure 12-b shows
the location of duodenal ulcer and gastric ulcer.
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