Lupus: An Autoimmune Disease
Involving RNA Processing
Systemic lupus erythematosus (SLE) is an
autoimmune disease thatcan have fatal consequences. It starts, usually in late
adolescence or early adulthood, with a rash on the forehead and cheekbones,
giving the wolflike appearance from which the disease takes its name. (Lupus means “wolf” in Latin.) Severe
kidney damage may follow, along with arthritis, accumulation of fluid around
the heart, and inflammation of the lungs. About 90% of lupus patients are
women. It has been established that this disease is of autoimmune origin,
specifically from the production of antibodies to one of the snRNPs, U1-snRNP. This snRNP is so designated
because it contains a uracil-rich RNA, U1-snRNA, which recognizes the 5' splice
junction of mRNA. Because the processing of mRNA affects every tissue and organ
in the body, this disease affects widely dispersed target areas and can spread
easily.
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