History
· Symptoms widespread and often insidious
· Enquire about previous endocrine gland problems, surgery, etc
· Major symptoms:
· Changes in appetite and weight:
· Bowel:
o Diarrhoea Þ hyperthyroidism or adrenal insufficiency
o Constipation Þ hypothyroidism or hypercalcaemia
· Sweating: hyperthyroidism, phaeochromocytoma, hypoglycaemia, acromegaly (also anxiety and menopause)
· Subcutaneous thinning: either ¯androgens (old men and post-menopausal women) or  Cortisol
· Amenorrhoea: ÂPRL (by only a little), ÂCortisol (takes bigger increase), ÂÂhyperthyroidism
· Nocturia: ¯ADH, or Diabetes from ¯insulin, Âcortisol or ÂGH
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