History
· Symptoms widespread and often insidious
· Enquire about previous endocrine gland problems, surgery, etc
· Major symptoms:
· Changes in appetite and weight:

· Bowel:
o Diarrhoea Þ hyperthyroidism or adrenal insufficiency
o Constipation Þ hypothyroidism or hypercalcaemia
· Sweating: hyperthyroidism, phaeochromocytoma, hypoglycaemia, acromegaly (also anxiety and menopause)
· Subcutaneous thinning: either ¯androgens (old men and post-menopausal women) or Cortisol
· Amenorrhoea: PRL (by only a little), Cortisol (takes bigger increase), hyperthyroidism
· Nocturia: ¯ADH, or Diabetes from ¯insulin, cortisol or GH
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