Immune mechanisms play a role in the pathogenesis of most glomerular diseases, either via deposition of immune complexes or injury from antibodies. Glomerular diseases may be divided into those originating in the kidney and those caused by systemic disease (secondary).
Glomerular disease may present clinically as nephrotic or nephritic syndrome.Their clinical features are different.
Renal biopsy can yield a definitive diagnosis when light microscopy features are considered in concert with immunofluoresence (IF) and electron microscopy (EM).
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