Immune mechanisms play a role
in the pathogenesis of most glomerular diseases, either via deposition of
immune complexes or injury from antibodies. Glomerular diseases may be divided
into those originating in the kidney and those caused by systemic disease
Glomerular disease may
present clinically as nephrotic or nephritic syndrome.Their clinical
features are different.
Renal biopsy can yield a
definitive diagnosis when light microscopy features are considered in concert
with immunofluoresence (IF) and electron microscopy (EM).