End-stage renal disease is the final stage of many forms of glomerular disease. It is characterized by progressive renal failure, uremia, and ultimately death.
Clinical features include anemia, anorexia, malaise, proteinuria, hypertension, and azotemia. Urinalysis shows broad, waxy casts. On pathologic examination, the kidneys are grossly small and shrunken; microscopic exam shows hyalinization of glomeruli, interstitial fibrosis, atrophy of tubules, and a lymphocytic infiltrate.
Treatment is dialysis and renal transplantation.