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Chapter: Modern Medical Toxicology: Miscellaneous Drugs and Poisons: Anti-Infectives

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Antiprotozoal Agents

Antimalarial Drugs, Antiamoebic Drugs, Antiamoebic Drugs.

Antiprotozoal Agents

Antimalarial Drugs

Tissue Schizontocides—chloroguanide (proguanil).

Blood Schizontocides—

–– Rapid acting—quinine, chloroquine, amodiaquine, quinidine, mefloquine, halofantrine, and endoper-oxides (qinghaosu).

––  Slow acting—antifolate (pyrimethamine and sulf-adoxine), and antibiotic compounds (tetracyclines).

Gametocytocides—chloroquine, quinine, and primaquine.

Sporontocides—chloroquine.

Antiamoebic Drugs

Luminal amoebicides—diloxanide furoate, quini-dochlor, and clioquinol (iodochlorhydroxyquin).

Systemic amoebicides—emetine, dehydroemetine, and chloroquine.

Mixed amoebicides—5-nitroimidazoles.

– Other Antiprotozoal Drugs: sodium stiboglu-conate.

Antihelminthic Agents

1.  Benzimidazoles

2.  Diethylcarbamazine

3.  Niclosamide

4.  Piperazine

5.  Praziquantel

6.  Pyrantel pamoate

7.  Levamisole.

The toxicity of some of the important drugs will be discussed here.

 

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