Antimetabolite drugs
Because antimetabolite drugs structurally
resemble DNA basepairs, they can
become involved in processes associated withDNA
base pairs—that is, the synthesis of nucleic acids and proteins.
Antimetabolites differ
sufficiently from DNA base pairs in howthey interfere with this
synthesis. Because the antimetabolites arecell cycle–specific and
primarily affect cells that actively synthesize DNA, they’re referred to as S phase–specific. Normal cellsthat are reproducing actively, as well as the cancer
cells, are affected by the antimetabolites.
These drugs are subclassified according to the
metabolite affected and include:
·
folic acid analogues
·
pyrimidine analogues
·
purine analogues.
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