Alkylating drugs, given alone or with other drugs, effectively
actagainst various malignant neoplasms. These drugs fall into one of six
All of these drugs produce their antineoplastic
effects by damag-ing deoxyribonucleic acid (DNA). They halt DNA’s replication
process by cross-linking its strands so that amino acids don’t pair up
correctly. Alkylating drugs are cell cycle–phase nonspecific. This means that
their alkylating actions may take place at any phase of the cell cycle.