HYPOTHYROIDISM
Hypothyroidism can be caused by autoimmune
dis-ease (eg, Hashimoto’s thyroiditis), thyroidectomy, radioactive iodine,
antithyroid medications, iodine deficiency, or failure of the
hypothalamic–pituitary axis (secondary hypothyroidism). Hypothyroidism during
neonatal development results in cretinism, a condition marked by physical and
mental retarda-tion. Clinical manifestations of hypothyroidism in the adult are
usually subtle and include infertility, weight gain, cold intolerance, muscle
fatigue, leth-argy, constipation, hypoactive reflexes, dull facial expression,
and depression. Heart rate, myocar-dial contractility, stroke volume, and
cardiac out-put decrease, and extremities are cool and mottled because of
peripheral vasoconstriction. Pleural, abdominal, and pericardial effusions are
common. Hypothyroidism may be diagnosed by an elevated TSH concentration, or a
reduced free (or total) T 3 level, or both. Primary hypothyroidism, the more common condition, is
differentiated from secondary disease by an elevation in TSH in the former.
Normal concentrations of TSH despite reduced T3 concentra-tions (the so-called “euthyroid sick” syndrome) are often
seen in critical illness. The treatment of hypo-thyroidism consists of oral
replacement therapy with a thyroid hormone preparation, which takes several
days to produce a physiological effect and several weeks to evoke clear-cut
clinical improvement.
Myxedema coma results from extreme
hypothy-roidism and is characterized by impaired mentation, hypoventilation,
hypothermia, hyponatremia (from inappropriate antidiuretic hormone secretion),
and congestive heart failure. It is more common in elderly patients and may be
precipitated by infection, surgery, or trauma. Myxedema coma is a
life-threat-ening disease that can be treated with intravenous T3. T4 should not be used in this circumstance to avoid the need for
peripheral conversion to T3. The ECG should be monitored during therapy to detect myo-cardial
ischemia or arrhythmias. Steroid replacement (eg, hydrocortisone, 100 mg
intravenously every 8 h)is routinely given due to frequent coexisting adrenal
gland suppression. Some patients may require venti-latory support and external
warming.
Patients with uncorrected severe hypothyroidism or myxedema coma should
not undergo elective sur-gery. Such patients should be treated with T3
intra-venously prior to emergency surgery. Although a euthyroid state is ideal,
mild to moderate hypothy-roidism does not appear to be an absolute
contra-indication to surgery, for example, urgent coronary bypass surgery.
Hypothyroid patients usually require minimal preoperative sedation and
are very prone to drug-induced respiratory depression. In addition, they may
fail to respond to hypoxia with increased min-ute ventilation. Patients who
have been rendered euthyroid may receive their usual dose of thyroid medication
on the morning of surgery; it must be remembered, however, that most commonly
used preparations have long half-lives (the half-life of T 4 is about
8 days); therefore, omission of a single dose should have no medical
importance.
Clinically hypothyroid patients are more
sus-ceptible to the hypotensive effect of anestheticagents because of their
diminished cardiac output, blunted baroreceptor reflexes, and decreased
intra-vascular volume. For these reasons, ketamine or etomidate can be
recommended for induction of anesthesia. The possibility of coexistent primary
adrenal insufficiency should be considered in cases of refractory hypotension.
Other potential coex-isting conditions include hypoglycemia, ane-mia,
hyponatremia, difficulty during intubation because of a large tongue, and
hypothermia from a low basal metabolic rate.
Recovery from general anesthesia may be delayed in hypothyroid patients by hypothermia, respiratory depression, or slowed drug biotransformation; thus these patients may require mechanical ventilation. Because hypothyroidism increases vulnerability to respiratory depression, a multimodal approach to postoperative pain management, rather than strict reliance on opioids would be appropriate.
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