Pulmonary aspiration of gastric contents and failed endotracheal intubation are the major causes of maternal morbidity and mortality associated with general anesthesia. All patients should receive pro-phylaxis against aspiration pneumonia with 30 mL of 0.3 M sodium citrate 30–45 min prior to induc-tion. Patients with additional risk factors pre-disposing them to aspiration should also receive intravenous ranitidine, 50 mg, or metoclopramide, 10 mg, or both, 1–2 h prior to induction; such fac-tors include morbid obesity, symptoms of gastro-esophageal reflux, a potentially difficult airway, or emergent surgical delivery without an elective fast-ing period. Premedication with oral omeprazole, 40 mg, at night and in the morning also appears to be highly effective in high-risk patients undergoing elective cesarean section. Although anticholinergics theoretically may reduce lower esophageal sphinc-ter tone, premedication with glycopyrrolate (0.1 mg) helps reduce airway secretions and should be con-sidered in patients with a potentially difficult airway.
Anticipation of a difficult endotracheal intuba-tion may help reduce the incidence of failed intuba-tions. Examination of the neck, mandible, dentition, and oropharynx often helps predict which patients may have problems. Useful predictors of a diffi-cult intubation include Mallampati classification, short neck, receding mandible, prominent maxil-lary incisors, and history of difficult intubation . The higher incidence of failed intuba-tions in pregnant patients compared with nonpreg-nant surgical patients may be due to airway edema, a full dentition, or large breasts that can obstruct the handle of the laryngoscope in patients with short necks. Proper positioning of the head and neck may facilitate endotracheal intubation in obese patients: elevation of the shoulders, flexion of the cervical spine, and extension of the atlantooccipital joint (Figure 41–2). A variety of laryngoscope blades, a short laryngoscope handle, at least one extra stiletted endotracheal tube (6 mm), Magill forceps (for nasal intubation), a laryngeal mask airway (LMA), an intu-bating LMA (Fastrach), a fiberoptic bronchoscope,
a video-assisted laryngoscope (GlideScope or Stortz CMAC), the capability for transtracheal jet ventila-tion, and possibly an esophageal–tracheal Combitube should be readily available .
When potential difficulty in securing the air-way is suspected, alternatives to the standard rapid-sequence induction with conventional laryngoscopy, such as regional anesthesia or awake fiberoptic tech-niques, should be considered. We have found that video-assisted laryngoscopy has greatly reduced the incidence of difficult or failed tracheal intubation at our institutions. Moreover, a clear plan should be formulated for a failed endotracheal intubation following induction of anesthesia (Figure 41–3). In the absence of fetal distress, the patient should be awakened, and an awake intubation, with regional or local (infiltration) anesthesia, may be tried. In the presence of fetal distress, if spontaneous or positive-pressure ventilation (by mask or LMA) with cricoid pressure is possible, delivery of the fetus may be attempted. In such instances, a potent volatile agent with oxygen is employed for anesthesia, but once the fetus is delivered, nitrous oxide may be added to reduce the concentration of the volatile agent; sevo-flurane may be the best volatile agent because it may be least likely to depress ventilation. The inability to ventilate the patient at any time may require imme-diate cricothyrotomy or tracheostomy.
· The patient is placed supine with a wedge under the right hip for left uterine displacement.
· Denitrogenation is accomplished with 100% oxygen for 3–5 min while monitors are applied.
· The patient is prepared and draped for surgery.
· When the surgeons are ready, a rapid-sequence induction with cricoid pressure is performed using propofol, 2 mg/kg, or ketamine,
· 1–2 mg/kg, and succinylcholine, 1.5 mg/ kg. Ketamine is used instead of propofol in hypovolemic patients. Other agents, including methohexital and etomidate, offer little benefit in obstetric patients.
· With few exceptions, surgery is begun only after proper placement of the endotracheal tube is confirmed. Excessive hyperventilation (Paco2 25 mm Hg) should be avoided because it can reduce uterine blood flow and has been associated with fetal acidosis.
· Fifty percent nitrous oxide in oxygen with up to 0.75 MAC of a low concentration of volatile agent (eg, 1% sevoflurane, 0.75% isoflurane, or 3% desflurane) is used for maintenance of anesthesia. The low dose of volatile agent helps ensure amnesia but is generally not enough to cause excessive uterine relaxation or prevent uterine contraction following oxytocin. A muscle relaxant of intermediate duration (atracurium, cisatracurium, or rocuronium) is used for relaxation, but may exhibit prolonged neuromuscular blockade in patients who are receiving magnesium sulfate.
· After the neonate and placenta are delivered, 20–80 units of oxytocin are added to the first liter of intravenous fluid, and another 20 units to the next. Additional intravenous agents, such as propofol, opioid, or benzodiazepine, can be given to ensure amnesia.If the uterus does not contract readily, an opioid should be given, and the halogenated agent should be discontinued. Methylergonovine (Methergine), 0.2 mg intramuscularly or in 100-mL normal saline as slow intravenous infusion, may also begiven but can increase arterial blood pressure. 15-Methylprostaglandin F2α (Hemabate), 0.25 mg intramuscularly, may also be used.
· An attempt to aspirate gastric contents may be made via an oral gastric tube to decrease the likelihood of pulmonary aspiration on emergence.
· At the end of surgery, muscle relaxants are completely reversed, the gastric tube (if placed) is removed, and the patient is extubated while awake to reduce the risk of aspiration.
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