Ethylenimines
Although thiotepa is
chemically less reactive than the ni-trogen mustards, it is thought to act by
similar mecha-nisms. Its oral absorption is erratic. After intravenous
in-jection, the plasma half-life is less than 2 hours. Urinary excretion
accounts for 60 to 80% of eliminated drug.
Thiotepa has antitumor
activity against ovarian and breast cancers and lymphomas. However, it has been
largely supplanted by cyclophosphamide and other ni-trogen mustards for
treatment of these diseases. It is used by direct instillation into the bladder
for multifo-cal local bladder carcinoma.
Nausea and myelosuppression
are the major toxici-ties of thiotepa. It is not a local vesicant and has been
safely injected intramuscularly and even intrathecally.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.