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Isoproterenol is of interest because it is a pure β-agonist. β1-Effects increase heart rate, contractil-ity, and cardiac output. Systolic blood pressure may increase or remain unchanged, but β2-stimulation decreases peripheral vascular resistance and dia-stolic blood pressure. Myocardial oxygen demand increases while oxygen supply falls, making iso-proterenol or any pure β-agonist a poor inotropic choice in most situations.
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