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Chapter: Clinical Anesthesiology: Clinical Pharmacology: Adrenergic Agonists & Antagonists

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Adrenergic Agonists: Dopexamine

Dopexamine, a structural analogue of DA, has potential advantages over DA because it has less β1-adrenergic (arrhythmogenic) and α-adrenergic effects.

DOPEXAMINE

Clinical Considerations

Dopexamine, a structural analogue of DA, has potential advantages over DA because it has less β1-adrenergic (arrhythmogenic) and α-adrenergiceffects. Because of the decreased β-adrenergic effects and its specific effect on renal perfusion, it may have advantages over dobutamine. The drug has been clinically available in many countries since 1990, but has not gained widespread acceptance in practice.

Dosing & Packaging

Dopexamine infusion should be started at a rate of 0.5 mcg/kg/min, increasing to 1 mcg/kg/min at intervals of 10–15 min to a maximum infusion rate of 6 mcg/kg/min.

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