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Chapter: Clinical Anesthesiology: Clinical Pharmacology: Adrenergic Agonists & Antagonists

Adrenergic Agonists: Isoproterenol

Isoproterenol is of interest because it is a pure β-agonist.

ISOPROTERENOL

Isoproterenol is of interest because it is a pure β-agonist. β1-Effects increase heart rate, contractil-ity, and cardiac output. Systolic blood pressure may increase or remain unchanged, but β2-stimulation decreases peripheral vascular resistance and dia-stolic blood pressure. Myocardial oxygen demand increases while oxygen supply falls, making iso-proterenol or any pure β-agonist a poor inotropic choice in most situations.

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Clinical Anesthesiology: Clinical Pharmacology: Adrenergic Agonists & Antagonists : Adrenergic Agonists: Isoproterenol |

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