ACUTE TUBULAR INJURY
Acute tubular injury (ATI) is acute renal failure
associated with potentially revers-ible injury to the tubular epithelium. It is
the most common cause of acute renal failure in the United States. It is
characterized by oliguria with elevation of blood urea nitrogen (BUN) and
creatinine; metabolic acidosis and hyperkalemia; and dirty brown granular casts
and epithelial casts on urinalysis.
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Ischemic acute tubular
necrosis is the most common cause of ATI. The condi-tion is due to decreased
blood flow caused by severe hemorrhage, severe renal vasoconstriction,
hypotension, dehydration, or shock.
•
Nephrotoxic ATN has a large number of causes,
including drugs (e.g., poly-myxin, methicillin, gentamicin, sulfonamides);
radiographic contrast agents; heavy metals (e.g., mercury, lead, gold); organic
solvents (e.g., carbon tetra-chloride, chloroform, methyl alcohol); ethylene
glycol (antifreeze); mushroom poisoning; phenol; pesticides; and myoglobin.
The prognosis is excellent if the patient survives the underlying
disease, and if the patient had no preexisting kidney disease.
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