Chapter: Medicine and surgery: Nutritional and metabolic disorders

Vitamin B6 (pyridoxine) deficiency

Deficiency of pyridoxine is rarely a primary disorder, but it does occur as a secondary disorder. - Definition, Incidence, Aetiology, Pathophysiology, Clinical features, Complications, Investigations, Management, Prognosis.

Vitamin B6 (pyridoxine) deficiency

 

Definition

 

Deficiency of pyridoxine is rarely a primary disorder, but it does occur as a secondary disorder.

 

Aetiology

 

Important sources of Vitamin B6 are similar to those of the other B vitamins: liver, meat, whole grain cereals, vegetables and nuts. Deficiency may occur with malabsorption such as coeliac disease, dietary lack in alcoholism and drug toxicity especially isoniazid.

 

Pathophysiology

 

Pyridoxine is important in the metabolism of amino acids, especially tryptophan to nicotinic acid. In some rare metabolic disorders, pyridoxine deficiency is associated with infantile convulsions and sideroblastic anaemia.

 

Clinical features

 

Marginal deficiency may cause stomatitis, glossitis, dry lips, irritability and confusion. Deficiency causes mental confusion, glossitis, dry skin lesions and peripheral neuropathy.

 

Management

 

Oral replacement; however, high doses may cause neurotoxicity.

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Medicine and surgery: Nutritional and metabolic disorders : Vitamin B6 (pyridoxine) deficiency |


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