Vitamin B6 (pyridoxine) deficiency
Deficiency of pyridoxine is rarely a primary disorder, but it does occur as a secondary disorder.
Important sources of Vitamin B6 are similar to those of the other B vitamins: liver, meat, whole grain cereals, vegetables and nuts. Deficiency may occur with malabsorption such as coeliac disease, dietary lack in alcoholism and drug toxicity especially isoniazid.
Pyridoxine is important in the metabolism of amino acids, especially tryptophan to nicotinic acid. In some rare metabolic disorders, pyridoxine deficiency is associated with infantile convulsions and sideroblastic anaemia.
Marginal deficiency may cause stomatitis, glossitis, dry lips, irritability and confusion. Deficiency causes mental confusion, glossitis, dry skin lesions and peripheral neuropathy.
Oral replacement; however, high doses may cause neurotoxicity.