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Chapter: Modern Medical Toxicology: Cardiovascular Poisons: Diurets, Antihypertensives and Antiarrhythmics

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Vasodilators - Sympatholytic Drug Cardiovascular Poison

Vasodilators are used in the management of hypertension and peripheral vascular disease.

Vasodilators

Vasodilators are used in the management of hypertension and peripheral vascular disease. Examples include buflomedil, cadralazine, diazoxide, dihydralazine, fenoldopam, hydrala-zine, isoxsuprine, minoxidil, molsidomine, nicotinyl alcohol, sodium nitroprusside, and todralazine.

Hydralazine, dihydralazine, cadralazine, minoxidil, diazoxide and buflomedil are all peripheral vasodilators; their dilatory effect is greater on arterioles than on veins. Diastolic blood pressure is frequently lowered more than systolic. An increase in heart rate, stroke volume and cardiac output is commonly seen.


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