ANTIARRHYTHMICS
Cardiac
arrhythmias can be benign or malignant, and a wide array of drugs exist for
their treatment or control.
Vaughan Williams’ classification of
antiarrhy-thmicdrugs—
· Class I: Sodium channel blockers
o
Moderate to marked sodium channel
blockade —disop-yramide,
procainamide, quinidine.
o
Mild to moderate sodium channel blockade—ligno-caine, phenytoin, mexiletine,
tocainide.
o
Marked sodium channel blockade—encainide,flecainide, moricizine,
propafenone.
· Class II: Beta adrenergic blockers: atenolol, esmolol,metoprolol,
propranolol, and timolol.
· Class III: Potassium channel blockers: acecainide,amiodarone, bretylium,
sotalol.
· Class IV: Calcium channel blockers: diltiazem, nicardi-pine,
nifedipine, verapamil.
· Unclassified: adenosine.
Several
of these drugs and their toxicities have been discussed elsewhere, and the
toxicities of only those drugs which have not been adequately dealt with in
other sections, will be discussed here.
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