Biotech product stability may vary when stored in different types of containers and syringes. Some products are only stable in plastic syringes, e.g., somatropin and erythropoietin, while others are stable in glass, polyvinyl chloride and polypropylene, e.g., aldesleukin. Batch prefilling of syringes is possible. However, it is important to make sure that programs. Determining how far in advance doses may be prepared is also an important consideration. G-CSF is stable in Becton Dickinson (B-D) disposable plastic syringes for up to 7 days (Amgen, 2004) while erythropoietin is stable for up to 14 days (Amgen, 2006). Aldesleukin is recommended to be adminis-tered in PVC although glass has been used in clinical trials with comparable results (Chiron, 2000). Solutions are stable for 48 hours when refrigerated. GM-CSF and G-CSF can be administered in either PVC or polypropylene (Berlex, 2004).
Many biotech products are sensitive to light. Manufacturer’s information usually suggests that products be protected from strong light until the product is used. Dornase-a is packaged in protective foil pouches by the manufacturer to protect it from light degradation and should be stored in these original light protective containers until use. For patients who travel, the manufacturer will provide special travel pouches on request (Genentech, 1994). Alteplase in the lyophi-lized form also needs to be protected from light but is not light sensitive when in solution (Genentech, 2005). Pharmacists must be aware of the specific storage requirements with respect to light for each of the products stocked in the pharmacy.