Intoxication with piroxicam or tenoxicam results in dizziness, blurred vision, and sometimes coma. Most cases of overdose develop no effects or mild effects consisting of lethargy and gastrointestinal upset. Severe overdose may cause hypoten-sion, coma, respiratory depression, gastrointestinal bleeding or acute renal insufficiency. Seizures can occur. Treatment is on symptomatic and supportive lines.