Nimesulide belongs to the sulfonanilide class of NSAIDs, and has rapidly gained in popularity as an anti-inflammatory drug with analgesic-antipyretic properties. It is said to have a good safety profile, and overdoses have so far rarely been reported. However, a few rare cases document fulminant hepatic failure in patients who were taking nimesulide regularly. These patients had increasing jaundice over a 7 to 10-day period, in addition to confusion, nausea, and vomiting. Despite liver transplantation, some patients died due to multi-organ failure. Today there are emerging concerns about the real safety profile of nimesulide.