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Chapter: Modern Medical Toxicology: Miscellaneous Drugs and Poisons: Analgesics and Antihistamines

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Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Classification of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID)

Classification

  Pyrazolones—oxyphenbutazone, phenylbutazone.

  Propionic acids—benoxaprofen, carprofen, fenbufen,fenoprofen, flurbiprofen, ibuprofen, ketoprofen, naproxen, oxaprozin, pirprofen, suprofen, tiaprofenic acid.

  Fenamic acids—flufenamic acid, meclofenamic acid,mefenamic acid.

  Heterocyclic acetic acids—etodolac, indomethacin,ketorolac, sulindac, tolmetin, zomepirac.

  Aryl acetic acids—diclofenac, alclofenac.

  Oxicams—isoxicam, piroxicam, tenoxicam.

  Sulfonanilide—nimesulide.

Mode of Action

The mode of action of all NSAIDs is similar—inhibition of synthesis of prostaglandins, prostacyclins, and thromboxane, by binding to cyclo-oxygenase. Most NSAIDs can cause nephro-toxicity on long-term administration (analgesic nephropathy). Regular monitoring of serum creatinine in patients receiving such drug therapy is advisable.

 

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