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Chapter: Clinical Anesthesiology: Clinical Pharmacology: Cholinesterase Inhibitors & Other Pharmacologic Antagonists to Neuromuscular Blocking Agents

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Non Classic Reversal Agents

Besides cholinesterase inhibitors, two unique drugs (sugammadex and L-cysteine) are currently under investigation in the United States;

NON CLASSIC REVERSAL AGENTS

Besides cholinesterase inhibitors, two unique drugs (sugammadex and L-cysteine) are currently under investigation in the United States; these agents act as selective antagonists of nondepolarizing neuro-muscular blockade. Sugammadex is able to reverse aminosteroid-induced neuromuscular blockade, whereas cysteine has been shown to reverse the neuromuscular blocking effects of gantacurium and other fumarates.

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