Linear
IgA bullous disease
This
is clinically similar to pemphigoid, but affects children as well as adults.
Blisters arise on urticarial plaques, and are more often grouped, and on
extensor surfaces, than is the case with pemphigoid. The so-called ‘string of
pearls sign’, seen in some affected children, is the presence of blistering
around the rim of polycyclic urticarial lesions. The conjunctivae may be
involved. Linear IgA bullous disease is, as its name implies, associated with
linear deposits of IgA and C3 at the basement membrane zone (Fig. 9.5). IgG is
sometimes also found. The disorder responds well to oral dapsone.
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