Home | | Clinical Dermatology | Dermatitis herpetiformis

Chapter: Clinical Dermatology: Bullous diseases

Dermatitis herpetiformis

Dermatitis herpetiformis is a very itchy chronic subepidermal vesicular disease, in which the vesicles erupt in groups as in herpes simplexahence the name ‘herpetiformis’.

Dermatitis herpetiformis

Dermatitis herpetiformis is a very itchy chronic subepidermal vesicular disease, in which the vesicles erupt in groups as in herpes simplexahence the name ‘herpetiformis’.


Gluten-sensitive enteropathy, demonstrable by small bowel biopsy, is always present, but most patients do not suffer from diarrhoea, constipation or mal-nutrition as the enteropathy is mild, patchy and involves only the proximal small intestine. Absorption of gluten, or another dietary antigen, may form cir-culating immune complexes that lodge in the skin. A range of antibodies can be detected, notably directed against reticulin, gliadin and endomysiumaa com-ponent of smooth muscle. Granular deposits of IgA and C3 in the superficial dermis under the basement membrane zone (Fig. 9.5) induce inflammation, which then separates the epidermis from the dermis. These deposits clear slowly after the introduction of a gluten-free diet.


The extremely itchy, grouped vesicles (Fig. 9.9) and urticated papules develop particularly over the elbows (Fig. 9.10) and knees, buttocks and shoulders. They are often broken by scratching before they reach any size. A typical patient therefore shows only grouped excoriations, sometimes with eczema-like changes added by scratching.


The condition typically lasts for decades.


The complications of gluten-sensitive enteropathy include diarrhoea, abdominal pain, anaemia and, rarely, malabsorption. Small bowel lymphomas have been reported, and the use of a gluten-free diet may reduce this risk. There is a proven association with other autoimmune diseases, most commonly of the thyroid. Treatment, notably with dapsone, can cause side-effects.

Differential diagnosis

The disorder masquerades as scabies, an excoriated eczema, insect bites or neurodermatitis.


If a vesicle can be biopsied before it is scratched away, the histology will be that of a subepidermal blister, with neutrophils packing the adjacent dermal papil-lae. Direct immunofluorescence of uninvolved skin shows granular deposits of IgA, and usually C3, in the dermal papillae and superficial dermis (Fig. 9.5). Small bowel biopsy is no longer recommended as routine because the changes are often patchy. Tests for malabsorption are seldom needed.


The disorder responds to a gluten-free diet, which should be supervised by a dietitian. Adherence to this can be monitored using the titre of antiendomysial antibody, which should fall if gluten is strictly avoided. 

The bowel changes revert quickly to normal but IgA deposits remain in the skin, and the skin disease can drag on for many months. Because of this, and because a gluten-free diet is hard to follow and enjoy, some patients prefer to combine the diet with dapsone or sulphapyridine (sulfapyridine) at the start, although both can cause severe rashes, haemolytic anaemia (especially in those with glucose-6-phosphate dehydrogenase deficiency), leucopenia, thrombocytopenia, methaemoglobinaemia and peri-pheral neuropathy. Regular blood checks are therefore necessary.


Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Clinical Dermatology: Bullous diseases : Dermatitis herpetiformis |

Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.