Home | | Microbiology and Immunology | Cell Wall Components and Antigenic Structure - Treponema pallidum

Chapter: Microbiology and Immunology: Bacteriology: Treponema, Borrelia and Leptospira

Cell Wall Components and Antigenic Structure - Treponema pallidum

T. pallidum is antigenically complex. Infection by the bacteriainduces production of at least three types of antibodies against (a) cardiolipin antigen, (b) group-specific antigens, and (c) species-specific antigens of T. pallidum.

Cell Wall Components and Antigenic Structure

T. pallidum is antigenically complex. Infection by the bacteriainduces production of at least three types of antibodies against (a) cardiolipin antigen, (b) group-specific antigens, and (c) species-specific antigens of T. pallidum.

 Cardiolipin antigen

The cardiolipin antigen is a hapten and is chemically a diphosphatidyl glycerol. This hapten elicits the production of an antibody, known as reagin antibody, in blood of patient suf-fering from syphilis. This cardiolipin antigen is demonstrated in T. pallidum, but it is not known whether the reagin antibody is produced by cardiolipin that is present in the treponema or by the cardiolipin that is released from damaged tissues following infection by treponema.

      Demonstration of the reaginic antibodies in the serum against the cardiolipin antigen forms the basis of standard non-specific tests for syphilis (e.g., VDRL, Kahn, and Wasserman).

 T. pallidum group-specific antigen

T. pallidum group-specific antigen is protein in nature. It isfound in T. pallidum as well as in nonpathogenic cultivable treponemes, such as Reiter’s treponeme. This antigen induces the production of antibodies in the serum, which are found in patients with syphilis. Reiter’s protein complex complement fixation test, a test used in syphilis serology, employs this anti-gen for detection of serum antibodies in patients with syphilis.

 T. pallidum species-specific antigen

Species-specific treponemal antigen is probably polysaccharide in nature. This antigen induces the development of antibodies, which can be detected in serum of the patients suffering from syphilis. The specific treponemal test, such as T. pallidum hemagglutination (TPHA) test, detects antibodies by using these antigens.

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Microbiology and Immunology: Bacteriology: Treponema, Borrelia and Leptospira : Cell Wall Components and Antigenic Structure - Treponema pallidum |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.