Home | | Anesthesiology | Anesthesia for Coagulation in Liver Disease

Chapter: Clinical Anesthesiology: Anesthetic Management: Anesthesia for Patients with Liver Disease

| Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail |

Anesthesia for Coagulation in Liver Disease

In stable chronic liver disease, the causes of exces-sive bleeding primarily involve severe thrombocyto-penia, endothelial dysfunction, portal hypertension, renal failure, and sepsis.

COAGULATION IN LIVER DISEASE

 

In stable chronic liver disease, the causes of exces-sive bleeding primarily involve severe thrombocyto-penia, endothelial dysfunction, portal hypertension, renal failure, and sepsis. However, the hemostatic changes that occur with liver disease may cause hypercoagulation and thrombosis, as well as an increased risk of bleeding. Clot breakdown may be enhanced by an imbalance of the fibrinolytic system.

 

Chronic liver disease is characterized by the impaired synthesis of coagulation factors, resulting in prolongation of the prothrombin time (PT) and international normalized ratio (INR) (Table 33–1). However, the anticoagulant factors (protein C, anti-thrombin, and tissue factor pathway inhibitor) are also reduced and may balance out any effect of a prolonged PT. This may be confirmed by assessing thrombin generation in the presence of endothelial-produced thrombomodulin. Adequate thrombin production requires an adequate number of functioning platelets. If the platelet count is >60,000/μL, coagulation may well be normal in a patient with severe cirrhosis.

 

The patient with cirrhosis will typically have hyperfibrinolysis. However, there is a delicate bal-ance between the activators and inactivators that regulate the conversion of plasminogen to plasmin, and, therefore, individual laboratory tests may not give a true picture of the state of fibrinolysis. The thromboelastography (TEG ®), rotational thrombo-elastometry (ROTEM®), and Sonoclot® technolo-gies are the optimal methods of demonstrating the global state of the coagulation system at a specific moment in time in any patient with liver disease.


Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail


Copyright © 2018-2020 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.