Would
you choose general anesthesia (with endotra-cheal intubation, with a laryngeal
mask airway) or a neuraxial block for this patient?
Regional anesthesia would be preferable since
airway instrumentation can be avoided. However, a reduction in risk has been
shown only for patients with ongoing bronchospasm. Groebel et al. (1994)
reported that high thoracic epidural did not alter airway resistance and did
attenuate the response to provocation tests in patients with bronchial
hyperreactivity.
One concern with neuraxial block is the change
in pul-monary function due to high block, but the reduction in expiratory
reserve volume usually does not impair breath-ing. A theoretical concern is
sympathetic blockade with unopposed vagal action and bronchospasm. However, no
difference was found between parturients anesthetized with high epidurals (T2–T4)
and those receiving general anesthesia with ketamine and isoflurane.
The main issue with regional anesthesia is the
risk for failed block and the need for emergent intubation. Preparations should
be made for general anesthesia induction and intubation, and a difficult airway
should be recognized in advance. All attempts should be made, if this situation
arises, to obtain a deep plane of anesthesia before intubation to prevent
bronchospasm.
Laryngeal mask airway (LMA) insertion has been
shown to increase airway resistance less than endotracheal intubation and might
be preferable. However, the LMA does not protect against aspiration of gastric
contents, and administration of positive pressure ventilation through an LMA is
controversial.
Propofol appears to have a bronchodilator
effect and is currently the preferred agent for induction in asthmatics,
provided they are not allergic to eggs or soy. Ketamine is also among the first
choices for induction because of its sympathetic-stimulating action. Lidocaine
1.5 mg/kg IV administered 1–3 minutes before intubation prevents reflex
bronchoconstriction. Intratracheal lidocaine may trigger bronchospasm and
should be avoided. All volatile anesthetics are bronchodilators. A recent study
suggests that halothane and sevoflurane are better bronchodilators than
isoflurane at doses <1.7 MAC, but the clinical signifi-cance is unclear.
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