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Chapter: Biochemistry: Glycolysis

What Is the Connection between Anaerobic Metabolism and Dental Plaque?

Dental caries, or tooth decay, is one of the most prevalent diseases in the United States and possibly in the world.

What Is the Connection between Anaerobic Metabolism and Dental Plaque?

Dental caries, or tooth decay, is one of the most prevalent diseases in the United States and possibly in the world, although modern treatments such as fluoride and flossing have greatly reduced its incidence in young people. Contributing factors in tooth decay are a combination of a diet high in refined sugars, the development of dental plaque, and anaerobic metabolism.

The high-sugar diet allows for rapid growth of bacteria in the mouth, and sucrose is perhaps the most efficiently used sugar because the bacteria can make their polysaccharide “glue” more efficiently from this nonreducing sugar. The bacteria grow in expanding sticky colonies, forming plaque on the tooth surface. The bacteria growing under the surface of the plaque must utilize anaerobic metabolism because oxygen does not diffuse readily through the waxy surface of dental plaque. The two predominant by-products, lactate and pyruvate, are relatively strong organic acids, and these acid products actually destroy the enamel sur-face. The bacteria, of course, grow rapidly in the pock holes. If the enamel is eaten all the way through, the bacteria grow even more readily in the softer dentin layer beneath the enamel.


Fluoridation results in a much harder enamel surface, and the fluoride may inhibit the metabolism of the bacteria. Daily flossing disrupts the plaque, and the anaerobic conditions never get started.

 

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Biochemistry: Glycolysis : What Is the Connection between Anaerobic Metabolism and Dental Plaque? |


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