ROLE OF FAT IN THE DEVELOPMENT OF ATHEROSCLESOSIS
Cholesterol and triglycerides are the main forms
of fat carried in the blood stream. These fats or lipids come partly from food,
(exogenous) and partly from the body's own production in the liver
(endogenous). Fats are not water soluble and hence cannot travel through the
Cholesterol is an important substance for the
functioning of the body. It is not fat but it is closely related to fat. It is
a compound chemical that is an essential component in the structure of cells
and is also involved in the formation of important hormones.
levels of cholesterol can contribute to atherosclerosis, in which the blood
vessels are narrowed by deposits of a fatty tissue called atheroma made up
largely of cholesterol, esters and triglycerides .
These deposits of fatty tissue causes thickening of the arterial wall,
loss of elasticity and narrowing of the lumen.
Most myocardial infarctions are due to atherosclerosis. Myocardial
infarction is a cardiac disability resulting from an inadequacy of the coronary
arterial system to meet the needs of the heart muscle for oxygen and nutrients.
It may be manifested as sudden death or as angina pectoris.
Angina pectoris refers to the tight, pressing
burning and severe pain across the chest that follows exertion and is a result
of inadequate oxygen to the myocardium.
High cholesterol levels in the blood stream lead
to more cholesterol being deposited in patches of atheroma and a greater risk
of severe atherosclerosis. The two major lipids, cholesterol (CHOL) and
triglyceride (TG) circulate in the blood as lipid protein complexes known as lipo
proteins. The major lipoprotein classes are chylomicrons (CH), very low-density
lipoproteins (VLDL), low density lipoproteins (LDL) and high density
LDL carries cholesterol from the liver to the periphery of the body and
thus tends to promote the development of coronary heart disease.
HDL brings cholesterol from the tissues back to the liver for safe
disposal. This is why HDL is referred to as good cholesterol and LDL as bad
Things that may
Increase HDL cholesterol by an increase in
Reduced intake of dietary fat and cholesterol
will reduce chylomicron
Reduced total fat, saturated fat and trans fatty
acid in the diet will reduce endogenous fat produced in the liver, as a result
VLDL is reduced.
High intake of GLOP - water soluble fiber
results in more cholesterol being lost in the intestine.
GLOP Guar gum, Legumes, Oat bran and Pectin.