Plummer–Vinson syndrome or Paterson–Brown–Kelly syndrome is an unusual combination of iron deficiency anaemia and dysphagia.
There is atrophic, inflamed mucosa in the pharynx and the upper oesophagus with the formation of a post-cricoid web. The dysphagia is thought to be due to oesophageal spasm.
Patients present with dysphagia, glossitis, koilonychia and iron deficiency anaemia. There is a high risk of upper oesophageal or pharyngeal malignancy.
Webs are dilated endoscopically to relieve obstruction, iron deficiency anaemia is treated. If malignancy occurs the prognosis is poor.