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Chapter: Medicine and surgery: Gastrointestinal system

Plummer Vinson syndrome - Disorders of the oesophagus

Plummer–Vinson syndrome or Paterson–Brown–Kelly syndrome is an unusual combination of iron deficiency anaemia and dysphagia. - Definition, Incidence, Aetiology, Pathophysiology, Clinical features, Complications, Investigations, Management, Prognosis.

Plummer-Vinson syndrome

 

Definition

 

Plummer–Vinson syndrome or Paterson–Brown–Kelly syndrome is an unusual combination of iron deficiency anaemia and dysphagia.

 

Aetiology/pathophysiology

 

There is atrophic, inflamed mucosa in the pharynx and the upper oesophagus with the formation of a post-cricoid web. The dysphagia is thought to be due to oesophageal spasm.

 

Clinical features

 

Patients present with dysphagia, glossitis, koilonychia and iron deficiency anaemia. There is a high risk of upper oesophageal or pharyngeal malignancy.

 

Management

 

Webs are dilated endoscopically to relieve obstruction, iron deficiency anaemia is treated. If malignancy occurs the prognosis is poor.

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Medicine and surgery: Gastrointestinal system : Plummer Vinson syndrome - Disorders of the oesophagus |


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