Red blood cell fragmentation
·Microangiopathic
haemolytic anaemias (MAHA): includes—HUS, TTP, giant
capillary haemangioma (Kasabach Merritt syndrome), and DIC.
·Infection:
e.g. meningococcal, pneumococcal,
malaria (black water fever-
intravascular haemolysis), viral haemorrhagic fevers, Clostridium perfringens.
·Burns.
·Mechanical:
e.g. prosthetic heart valves,
March haemoglobinuria.
·Hereditary
acanthocytosis: rare
genetic condition of abetalipoproteinaemia
with mental retardation, ataxia, retinitis pigmentosa, and steatorrhoea.
·Envenomation from several of the
worlds venomous snakes, spiders, etc.
Depend on underlying cause and
severity of anaemia.
·Hb d.
·Blood
film: reticulocytes,
nucleated RBC ii, RBC fragmentation, shistocytes, irregularly contracted
cells, microspherocytes, acanthocytes.
·Possible platelets ‘fall’ or
clotting prolongation with consumption.
·In malaria, visible parasites on
thick/thin blood film.
·Treat underlying disease.
·Correct haematological
abnormalities, e.g. blood +/– platelet transfusion, fresh frozen plasma to
correct clotting abnormalities.
Give iron or folate supplements if
required.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.