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Certain enzymes may exist in two or more forms which have the same catalytic activity but are distinct physically, chemically and electrophoretically. These forms exist in different tissues.
a. Lactate dehydrogenase exist in 5 different iso enzymic forms LD1, LD2, LD3, LD4, LD5 and perform the same function of the conversion of lactate to pyruvate. LD1 is predominant in heart and LD5 in muscle and liver.
b. Creatine kinase exist in 3 different iso enzymic forms BB, MM and MB. These isoenzymes perform the same function of conversion of creatine to creatine phosphate.
BB form exist in brain, MM form in muscle and MB form in heart.
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