![if !IE]> <![endif]>
Group II Metabotropic Glutamate Receptors
Metabotropic glutamate receptors are classified as “family 3’’ G-protein coupled receptors (GPCRs). Group II metabotropic receptors (that include mGluR2 and mGluR3 receptors) are ne-gatively coupled to adenylate cyclase, and the mGluR2 receptor subclass is found both pre- and extrasynaptically. Several lines of evidence indicate that glutamate activates these mGluR2 receptors, resulting in a rapid inhibition of glutamate release, creating a negative feedback loop (Schoepp, 2001; Scanzfani et al., 1997). Since activation of Group II metabotropic recep-tors appears to require an elevated glutamate concentration, an agonist at these receptors would effectively dampen glutama-tergic transmission (including activation of NMDA receptors) without remarkably affecting synaptic glutamate under resting conditions.
Based on these data and reports that telencephalic glutamate concentrations are rapidly elevated during stress
Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.