Evaluation of Therapy
·
Are the results of the study
valid?
o Was the assignment of patients to treatments randomised?
o Was follow-up complete? (Non-follow-ups may have died, etc ® bias)
o Were patients analysed in the groups to which they were randomised?
o Were patients and researchers „blind‟ to the treatment
o Were the groups similar at the start of the trial
o Other than the intervention, were the groups treated equally?
·
What were the results?
o How large was the treatment effect? RR, RRR, ARR
o How precise was the estimate of the treatment effect? Point estimate
& Confidence intervals. What is the P value?
·
Will the results help me in caring
for my patients?
o Can the results be applied to my patient care?
·
Were all clinically important
outcomes considered: were the outcomes relevant for the patient? Or was only a
benefit to intermediate outcomes considered?
·
Do treatment benefits out-weight
harms and costs? ARR and NNT/NNH
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