BIOLOGICAL ROLE
The primary function of the glycoprotein hormone FSH in the female is
the regulation of follicle growth. FSH is produced and secreted by the anterior
lobe of the pituitary, a gland at the base of the brain. Its target is the FSH
receptor at the surface of the granulosa cells that surround the oocyte. FSH
acts synergistically with oestrogens and LH to stimulate proliferation of these
granulosa cells, which leads to follicular growth. This process explains why
deficient endogenous production of FSH may cause infertility.
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