Antipsychotic Drugs: Drug Interactions

DRUG INTERACTIONS

Because of their multiple effects, antipsychotic drugs produce more important pharmacodynamic than phar-macokinetic interactions. The action of other CNS de-pressants may be enhanced, and concurrent use of tri-cyclic antidepressants or other agents with anticholiner-gic activity may cause additive CNS dysfunction and peripheral anticholinergic effects. The hypotensive ef- fects of an antipsychotic may be increased by diuretics, captopril, and other antihypertensive medications. Anti-psychotic agents are also susceptible to enhanced me-tabolism by inducers of microsomal mixed-function ox-idases.