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Chapter: Medicine Study Notes : Genetics and Cancer

Anatomic Pathology and Neoplasia - Cancer

Describing a histologic section – always include: o Architecture (eg gland formation, infiltration – eg sheet like, chords) o Cytologic atypia: hyperchromatic, nuclear pleomorphism, mitotically active

Anatomic Pathology and Neoplasia

 

·        Describing a histologic section – always include:

o  Architecture (eg gland formation, infiltration – eg sheet like, chords)

o  Cytologic atypia: hyperchromatic, nuclear pleomorphism, mitotically active

o  Tissue reaction (fibrosis, inflammation, etc)


·        Macroscopic signs of invasion:

o  Variegated

o  Poorly circumscribed, not encapsulated, irregular border

o  Crab like

o  Areas of haemorrhage


·        Microscopic signs of malignancy:

o  Nuclear pleomorphism

o  Hyperchromatic nuclei

o  Invasion

o  Poorly differentiated (anaplastic)

o  Mitoses


·        Tumor prognosis:

o  Stage (how much infiltration, metastasis)

o  Grade (what type, how well differentiated)

o  Resection margin

o  Brisk inflammatory response is good


·        Hamartoma = overgrowth of tissue native to that site (NOT clonal proliferation/neoplasm)

 

·        Headings for answering pathology exam essay questions:

o   Incidence

o   Aetiology

o   Pathogenesis

o   Macroscopic description

o   Microscopic description

o   Natural History

o   Outcome

o   Complications

o   Special types

 

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Medicine Study Notes : Genetics and Cancer : Anatomic Pathology and Neoplasia - Cancer |


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